The Port Huron & Lake Michigan Railroad, later the Grand Trunk Western, arrived here in 1870. The first depot burned in 1917, and makeshift quarters served for a decade. This depot was built in 1927, according to Grand Trunk’s specifications. In 1930 an addition was built on the west end of the depot.

The Imlay City museum is owned and operated by the Imlay City Historical Commission, which collects, preserves, and interprets the heritage of the Imlay City area and instills an appreciation of local history through exhibits and educational programs.